Pathophysiology of thrombocytopenia associated with HIV infection in homosexual men
Identifieur interne : 000475 ( Main/Exploration ); précédent : 000474; suivant : 000476Pathophysiology of thrombocytopenia associated with HIV infection in homosexual men
Auteurs : RBID : ISTEX:277_1989_Article_BF00320260.pdfEnglish descriptors
Abstract
The pathophysiology of HIV associated immune thrombocytopenia (HIV-ITP) and its response to AZT was investigated. Using autologous 111Indium-labelled platelets, platelet kinetic were analysed in two patient groups. Group 1 (untreated) was comprised of 13 patients with HIV-ITP. Group 2 (AZT) was comprised of 6 patients with a history of HIV-ITP prior to starting AZT. These patients were studied following a rise in their platelet count on AZT. Platelet survivals in both groups were shortened compared to controls, however there was no significant difference between the 2 groups. However platelet turnover rates were significantly depressed in Group 1 compared to Group 2 (P<0.05) and control values (P<0.05). The platelet count correlated with platelet turnover in Group 1 but not in AZT treated patients. Thus patients with HIV-ITP appear to have both shortened survivals and suppressed platelet production. The mechanism of the latter is unknown, but the increased turnover rate seen with AZT suggests it is a direct or indirect effect of the HIV virus.
DOI: 10.1007/BF00320260
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Belzberg</name><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, St. Paul's Hospital, Vancouver, B.C., Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, St. Paul's Hospital, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, St. Paul's Hospital, Vancouver, B.C., Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Nuclear Medicine, St. Paul's Hospital, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author><author><name>D. Devine</name><affiliation wicri:level="1"><mods:affiliation>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C., Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author><author><name>P. Doubroff</name><affiliation wicri:level="1"><mods:affiliation>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C., Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author><author><name>C. Mikulash</name><affiliation wicri:level="1"><mods:affiliation>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C., Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author><author><name>B. Spurston</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, St. Paul's Hospital, Vancouver, B.C., Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Nuclear Medicine, St. Paul's Hospital, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author><author><name>H. Chambers</name><affiliation wicri:level="1"><mods:affiliation>Department of Nursing, St. Paul's Hospital, Vancouver, B.C., Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Nursing, St. Paul's Hospital, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author><author><name>C. Sartori</name><affiliation wicri:level="1"><mods:affiliation>Department of Nuclear Medicine, St. Paul's Hospital, Vancouver, B.C., Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Nuclear Medicine, St. Paul's Hospital, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author><author><name>N. Buskard</name><affiliation wicri:level="1"><mods:affiliation>Department of Nursing, St. Paul's Hospital, Vancouver, B.C., Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Nursing, St. Paul's Hospital, Vancouver, B.C.</wicri:regionArea><wicri:noRegion>B.C.</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:277_1989_Article_BF00320260.pdf</idno><date when="1989">1989</date><idno type="doi">10.1007/BF00320260</idno><idno type="wicri:Area/Main/Corpus">000867</idno><idno type="wicri:Area/Main/Curation">000867</idno><idno type="wicri:Area/Main/Exploration">000475</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>HIV infection</term><term>Pathophysiology of thrombocytopenia</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The pathophysiology of HIV associated immune thrombocytopenia (HIV-ITP) and its response to AZT was investigated. Using autologous 111Indium-labelled platelets, platelet kinetic were analysed in two patient groups. Group 1 (untreated) was comprised of 13 patients with HIV-ITP. Group 2 (AZT) was comprised of 6 patients with a history of HIV-ITP prior to starting AZT. These patients were studied following a rise in their platelet count on AZT. Platelet survivals in both groups were shortened compared to controls, however there was no significant difference between the 2 groups. However platelet turnover rates were significantly depressed in Group 1 compared to Group 2 (P<0.05) and control values (P<0.05). The platelet count correlated with platelet turnover in Group 1 but not in AZT treated patients. Thus patients with HIV-ITP appear to have both shortened survivals and suppressed platelet production. The mechanism of the latter is unknown, but the increased turnover rate seen with AZT suggests it is a direct or indirect effect of the HIV virus.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="9716be8d6f8563e58406cc55f8a60804a4de3856"><titleInfo lang="eng"><title>Pathophysiology of thrombocytopenia associated with HIV infection in homosexual men</title><subTitle>A preliminary report</subTitle></titleInfo><name type="personal"><namePart type="given">P. J.</namePart><namePart type="family">Ballem</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation><affiliation>Department of Medicine, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Belzberg</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Medicine, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation><affiliation>Department of Nuclear Medicine, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Devine</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Doubroff</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Mikulash</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Canadian Red Cross BTS, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Spurston</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Chambers</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nursing, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Sartori</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nuclear Medicine, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Buskard</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Nursing, St. Paul's Hospital, Vancouver, B.C., Canada</affiliation></name><typeOfResource>text</typeOfResource><genre>Proceedings Of The International Workshop On ITP</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1988-11-26</dateCreated><dateValid encoding="w3cdtf">2004-08-26</dateValid><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">The pathophysiology of HIV associated immune thrombocytopenia (HIV-ITP) and its response to AZT was investigated. Using autologous 111Indium-labelled platelets, platelet kinetic were analysed in two patient groups. Group 1 (untreated) was comprised of 13 patients with HIV-ITP. Group 2 (AZT) was comprised of 6 patients with a history of HIV-ITP prior to starting AZT. These patients were studied following a rise in their platelet count on AZT. Platelet survivals in both groups were shortened compared to controls, however there was no significant difference between the 2 groups. However platelet turnover rates were significantly depressed in Group 1 compared to Group 2 (P<0.05) and control values (P<0.05). The platelet count correlated with platelet turnover in Group 1 but not in AZT treated patients. Thus patients with HIV-ITP appear to have both shortened survivals and suppressed platelet production. The mechanism of the latter is unknown, but the increased turnover rate seen with AZT suggests it is a direct or indirect effect of the HIV virus.</abstract><subject lang="eng"><genre>Key words</genre><topic>Pathophysiology of thrombocytopenia</topic><topic>HIV infection</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Blut</title></titleInfo><titleInfo><title>Blut</title><subTitle>Zeitschrift für die Gesamte Blutforschung</subTitle><partNumber>Year: 1989</partNumber><partNumber>Volume: 59</partNumber><partNumber>Number: 1</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1989-07-01</dateIssued><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Hematology</topic><topic>Oncology</topic></subject><identifier type="issn">0006-5242</identifier><identifier type="issn">Electronic: 1432-0584</identifier><identifier type="matrixNumber">277</identifier><identifier type="local">IssueArticleCount: 29</identifier><recordInfo><recordOrigin>Springer-Verlag, 1989</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00320260</identifier><identifier type="matrixNumber">Art21</identifier><identifier type="local">BF00320260</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>111</start><end>114</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1989</recordOrigin><recordIdentifier>277_1989_Article_BF00320260.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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